Nanofat: Injectable Treatment for Skin Rejuvenation
Nanofat is a injectable treatment that is a compact collection of your own stem cells, signaling molecules and lipid that has major regenerative and tissue remodeling potential. In other words, if we inject it after a procedure, we can amplify the healing process to maximize the results of less invasive treatments. This has been proven many times in controlled laboratory studies, wound healing studies and post-surgical studies. This improved healing effect makes sense when you analyze the composition of nanofat that includes all the cells and molecules that the skin needs to heal. It is not a fat transfer, it is pulling out the stem cells from the fat. It’s similar to PRP but more powerful, adds the components needed for healing and has sustained benefits. Truly the applications are endless, but Dr Compton currently uses it in a few situations where benefit has been proven. Currently these include, in combination with Morpheus radiofrequency microneedling, skin resurfacing, under eye, lip enhancement, scar revision, and for facial skin rejuvenation.
Nanofat is fat harvested from the abdomen though and tiny few millimeter incision in your belly button, that will not change the abdominal contours. The fat is washed, and processed to break apart the large fat cells and filter the stem cells, and signaling cells as well as free lipid. The nanofat is the part with stem cells, which is then injected under the skin in the treatment areas to maximize the healing. Nanofat is will not to provide structural change (filler effects) to the facial contours or volumize the face. (If this is desired, we do offer facial fat grafting to volumize the face)
Nanofat is similar to PRP (platelet rich plasma) in that they are both using your own cells to maximize healing, but nanofat is significantly better in so many ways. The first is that nanofat has an extracellular matrix (web in which cells live) to provide immediate support to the healing tissues. Nanofat has a large amount of free lipid component as well, which acts like an intense skin moisturizer from below. Most importantly the stem cells provided by nanofat are the correct cells for rebuilding soft tissue and organizing healing rather than scarring. They stay in the tissues for a long time providing signaling molecules for months to come. (PRP is considered a large one time hit of signaling molecules.) Many papers support the theory that these adipose derived cells are activated and work much better in this low oxygen healing environment (fat is mostly a low oxygen environment). There are also a whole host of cell signaling molecules which are present in the processed fat that provide an initial boost to the healing.
The stars of the show with nanofat are the adipose derived mesenchymal stromal cells which modulates the immune response to be anti-fibrotic (stops scar), enhancing organized collegen production, anti-inflammatory and stops cells from undergoing cell self-destruction. They start repairing the surgical damage by organizing and repairing the connective tissues, increasing blood vessel and lymphatic channel growth, and producing signaling molecules to modify the healing process in many ways. Unlike PRP (platelet rich plasma), these cells stay in this area and produce these signals on an ongoing basis rather than the one-time bump of PRP. They become the foreman of the healing process, and this sustained management over the months of healing allows the healing to be more organized and comprehensive.
The supporting cast in the nanofat is a product called microvascular fragments. These are pieces of the small blood vessels from the fat harvest that the healing area will put directly into play and start hooking into the local blood supply. This quickly improves the vascular supply to the healing tissues more efficiently and effectively than building new vessels from scratch.
Overall nanofat is a game changing injectable enhancement that maximizes the healing of our cosmetic surgeries and amplifies the benefits of our minimally invasive cosmetic procedures like Morpheus, lasers and resurfacing.